This gene does not have a cancer hallmark. You can see more information about hallmarks. COSMIC gene ITPKB (COSG226) Genomic coordinates 1:226631690..226739175 (negative strand) Synonyms IP3-3KB, IP3KB, CCDS1555.1, P27987, ENSG00000143772.9, NM_002221.3, NP_002212 COSMIC-3D No protein structures

ITPK1 mutation reduces labeling of InsP 6 by 50%, with concomitant accumulation of d / l ‐Ins(3,4,5,6)P 4, but because it does so without affecting the level of Ins(1,3,4,5,6)P 5 (Figures 5a and S6a) suggests that ITPK1 probably does not act as an Ins(1,3,4,5,6)P 5 1‐phosphatase.

Figure 1. Schematic of data sources for My Cancer Genome. Curated assertions on the My Cancer Genome website are housed within a Knowledge Management System (KMS) created through a partnership with GenomOncology that serves as a warehouse of biomarker, disease, and drug ontologies; biomarker-driven cancer clinical trials; therapeutic, prognostic, and diagnostic assertions; and unstructured ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism Yann Desfougèresa, Miranda S. C. Wilsona, Debabrata Lahaa, Gregory J. Millerb, and Adolfo Saiardia,1 Cancer Cell Int. 2019 Feb 14;19:32. doi: 10.1186/s12935-019-0754-9. eCollection 2019. Authors Yalu Liu 1 , Xiaogan Wang 1 , Lijuan Deng 1 , Lingyan Ping 1 This gene does not have a cancer hallmark. You can see more information about hallmarks.

Itpk1 cancer

COSMIC gene ITPKB (COSG226) Genomic coordinates 1:226631690..226739175 (negative strand) Synonyms IP3-3KB, IP3KB, CCDS1555.1, P27987, ENSG00000143772.9, NM_002221.3, NP_002212 COSMIC-3D No protein structures Kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6)P4 or Ins (1,3,4)P3. Phosphorylates Ins (3,4,5,6)P4 at position 1 to form Ins (1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins (3,4,5,6)P4 is an inhibitor of plasma membrane Ca 2+-activated Cl - channels, while Ins (1,3,4,5,6)P5 is not. Furthermore, ITPK1-AS1, KCNQ1DN, LINC00167, LINC00173 and LINC00307 may serve as biomarkers for GC pathogenesis.

ITPK1 (Inositol-Tetrakisphosphate 1-Kinase) is a Protein Coding gene. Diseases associated with ITPK1 include Neural Tube Defects. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Inositol phosphate metabolism.

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This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.

Figure 1. Schematic of data sources for My Cancer Genome. Curated assertions on the My Cancer Genome website are housed within a Knowledge Management System (KMS) created through a partnership with GenomOncology that serves as a warehouse of biomarker, disease, and drug ontologies; biomarker-driven cancer clinical trials; therapeutic, prognostic, and diagnostic assertions; and unstructured

The cancer tissue page shows antibody staining of the protein in 20 different cancers. ITPK1. Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene. It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis. Furthermore, ITPK1-AS1, KCNQ1DN, LINC00167, LINC00173 and LINC00307 may serve as biomarkers for GC pathogenesis. Keywords: gastric cancer; long non-coding RNAs; risk score system; survival curve; weighed gene co-expression network analysis. Figure 1.

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene. It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis. Furthermore, ITPK1-AS1, KCNQ1DN, LINC00167, LINC00173 and LINC00307 may serve as biomarkers for GC pathogenesis. Keywords: gastric cancer; long non-coding RNAs; risk score system; survival curve; weighed gene co-expression network analysis. Figure 1. Schematic of data sources for My Cancer Genome.
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It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis. ITPK1 mutation reduces labeling of InsP 6 by 50%, with concomitant accumulation of d / l ‐Ins(3,4,5,6)P 4, but because it does so without affecting the level of Ins(1,3,4,5,6)P 5 (Figures 5a and S6a) suggests that ITPK1 probably does not act as an Ins(1,3,4,5,6)P 5 1‐phosphatase. 1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142 People's Republic of China.

Description. FPKM. TCGA-D8-A1XF-01A: 45 years, female, white, stage:iia: 46.2: TCGA-AO-A0JD-01A: 59 years, female, white, stage:iiia: 45.4: TCGA-C8-A12M-01A Expression of ITPK1 in appendix tissue. Antibody staining with HPA055230 in immunohistochemistry.
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---. ---. nuclear. find_circ . 10 Aug 2020 Thus, IPMK and ITPK1 likely cooperate in the production of IP5 in cells.